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Surgery should be considered in patient with persistent culture positive MDR-TB despite effective medical treatment. If the patient has localized disease, reasonable lung function and only two or three (weak) drugs available, surgery should be seriously considered. Resection surgery is done as an adjunct to medical treatment.

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Espinal MA, Laszlo A, Simonsen L et al. Global trends in resistance to anti-tuberculosis drugs. N Engl J Med 2001; 344: 1294-1303.

WHO/ IUATLD global project on anti-tuberculosis drug resistance surveillance (1999-2002). Third Global Report (2004).

ICMR, Prevalence of drug resistance in patients with pulmonary tuberculosis presenting for the first time with symptoms at chest clinics in India. Findings in urban clinics among patients giving no history of previous chemotherapy. Indian J Med Res 1968; 56: 1617-1630.


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